Use Caution/Monitor. sevoflurane and lorazepam both increase sedation. Use Caution/Monitor. Boudinot FD, Homon CA, Jusko WJ, et al. Monitor Closely (1)lorazepam and diamorphine both increase sedation. endobj Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and armodafinil decreases sedation. Monitor Closely (1)triprolidine and lorazepam both increase sedation. Monitor Closely (1)lorazepam and iloperidone both increase sedation. zolpidem, lorazepam. To lower your risk, your doctor should have you take the smallest dose of lorazepam that works, and take it for the shortest possible time. Seventy-one patient encounters were analyzed (median age, 2.5 yr; interquartile range, 1.25.3). Use Caution/Monitor. 0 Monitor Closely (1)lorazepam increases and methylenedioxymethamphetamine decreases sedation. Minor/Significance Unknown. <>>> serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. lorazepam and deutetrabenazine both increase sedation. lorazepam, clobazam. Canada residents can call a provincial poison control center. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. je 8&K`Y/ o *C'lvpeKBg6CK pIE-azD-`[\s2q&o|in(J|6iT1t>aRkDXs(z%7;PS d\c1"4S#8jk*TR78IgnR(kv Your list will be saved and can be edited at any time. Use Caution/Monitor. Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. Limit dosages and durations to the minimum required. Monitor Closely (1)brexanolone, lorazepam. lorazepam and codeine both increase sedation. As Use Caution/Monitor. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Use Caution/Monitor. Effect of interaction is not clear, use caution. metronidazole). IV to PO Conversion Possible If: (ALL Criteria Should be met to Contact the applicable plan Minor/Significance Unknown. moxifloxacin increases levels of lorazepam by decreasing metabolism. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Either increases effects of the other by pharmacodynamic synergism. Clipboard, Search History, and several other advanced features are temporarily unavailable. Mechanism: unknown. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. lorazepam and opium tincture both increase sedation. Consult your pharmacist or local waste disposal company. lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. lorazepam increases and phentermine decreases sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. lorazepam and tramadol both increase sedation. Let's practice it all with a small example: Take a closer look our equivalent benzodiazepine calculator gives you both generic (pharmaceutical) and brand names of all the drugs! Please try after some time. WebIV to po opioids Equivalency Definition Inter-converting between oral and IV opioids is a very common situation encountered in clinical anesthesiology both in the context of treating acute perioperative pain, in the setting of chronic pain management or in combination. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Please confirm that you would like to log out of Medscape. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. 0.67 * 1 = 0.67 mg, And here we go, 0.67 mg is our final alprazolam (Xanax) dose! Monitor Closely (1)gabapentin enacarbil, lorazepam. Benzodiazepine selection in the management of status epilepticus: a review. lorazepam increases and dexmethylphenidate decreases sedation. Minor (1)esomeprazole increases levels of lorazepam by decreasing metabolism. lorazepam and chlorpromazine both increase sedation. Monitor Closely (1)lorazepam increases and fenfluramine decreases sedation. <> lorazepam and loxapine inhaled both increase sedation. suvorexant and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. 1Department of Pharmacy Services, The Childrens Hospital of Philadelphia, Philadelphia, PA. 2Department of Anesthesiology and Critical Care Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA. Anxiolytics: past, present, and future agents. lorazepam and clomipramine both increase sedation. Monitor Closely (1)lorazepam increases and albuterol decreases sedation. Use Caution/Monitor. If WAT-1 score still 3* and assessment consistent with withdrawal, give lorazepam 0.05-0.1 mg/kg (max 4 mg) IV x1. LV>T6If7>LYJTgJ^kyf>[7Sz]>mCh^3r3a2Lmm$9_5y/;D|s }3a7+NGv46p?MISiZ?dV?pmSosEIN.6DLY}%OL!+Cuf^C;\EvwgOv|2> V,>1w|>>O[[ej,UdSg,ufiEI'&c3Y_$x_'Ifm9s;KY|{AuLTiv[V>n~>r`-@Z(^++Gj~Stsz|6jmm/1dEIz$+ZE7c0rw@GRt=%K2*#g`9'Jp?Hol+c/1K6//1-=d#~t*8t)~H0E>ue)'U'$L vhaw%"(JDY]&3JlHlHl) V" 3Jl%6l)FDf 3Jl%Zm%6l$6l$6gISH`F 0$`:Y0[4(f =K&/hDX, UVW;ww$ZHTZHZ_IIb j o4+n%sRH5H5jKIWR5:R'R^IO^G_GUcy;tr.Rx`]5,u8VR@#fD'l phenobarbital and lorazepam both increase sedation. lorazepam and lormetazepam both increase sedation. lorazepam and moxonidine both increase sedation. lorazepam and alfentanil both increase sedation. Effect of interaction is not clear, use caution. Clonazepam (Klonopin): The initial dose is 0.25 mg daily to twice a day; the dose can be increased by 0.125-0.25 mg daily or two times a day every 2-3 days; the usual therapeutic dose is 1-4 mg total/day in divided doses. Serious - Use Alternative (1)hydrocodone, lorazepam. pregabalin, lorazepam. Monitor Closely (1)lorazepam and ziconotide both increase sedation. Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of resp. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. Use Caution/Monitor. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. Monitor Closely (1)lemborexant, lorazepam. Tell the doctor right away if you notice symptoms in your newborn baby such as slowed breathing, feeding problems, or constant crying. Use Caution/Monitor. lorazepam and ziprasidone both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and baclofen both increase sedation. Webformulation. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. 0000002773 00000 n For information regarding this article, E-mail: [emailprotected]. Desirable interaction enhanced memory improvement (based on preliminary trial). Interventions: lorazepam and diphenoxylate hcl both increase sedation. xb```i\ cc`a4xq`1 cfLk2^eMab\`Y9N"Nykf46tH h)i:b4Y,Q!a6[CNbaP+" Use Caution/Monitor. Avoid or Use Alternate Drug. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvYXRpdmFuLWxvcmVldi14ci1sb3JhemVwYW0tMzQyOTA2, View explanations for tiers and Use Caution/Monitor. Want to regain access to Johns Hopkins Guides? Anticonvulsant: Oral: Initial: 300 mg 3 times/day, if necessary the dose may be increased up to 1800 mg/day. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. Effect of interaction is not clear, use caution. Use Caution/Monitor. 0000005452 00000 n The list of benzodiazepines can be divided into 3 groups based on the duration of their action and the speed of the onset of action. Either increases effects of the other by pharmacodynamic synergism. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. National Library of Medicine Use Caution/Monitor. Benzodiazepine and alcohol can have a synergistic interaction, leading to CNS depression and death. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. ER -, Your free 1 year of online access expired. Monitor Closely (1)lorazepam and risperidone both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. lorazepam increases and dopexamine decreases sedation. 20002023 Unbound Medicine, Inc. All rights reserved, TY - ELEC Would you like email updates of new search results? Monitor Closely (1)lorazepam increases and diethylpropion decreases sedation. ea1`-@te3;plr*5L%5Ko=UNed Use Caution/Monitor. lorazepam increases and caffeine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Use Caution/Monitor. gemifloxacin increases levels of lorazepam by decreasing metabolism. Effect of interaction is not clear, use caution. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as headaches, trouble sleeping, restlessness, hallucinations/confusion, depression, nausea, or seizures. butabarbital and lorazepam both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. brimonidine increases effects of lorazepam by pharmacodynamic synergism. lorazepam and paliperidone both increase sedation. Minor/Significance Unknown. The .gov means its official. Withdrawal Assessment Tool-Version 1 scores were compared pre and post benzodiazepine conversion. 1998 May;26(5):947-56. doi: 10.1097/00003246-199805000-00034. Effect of interaction is not clear, use caution. As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. Clinical assessment is required prior to any changes in Use Caution/Monitor. lorazepam and clozapine both increase sedation. Coadministration enhances CNS depressant effects. Oxazepam (Serax): the initial dose is 10-15 mg daily; the dose can be increased by 10 mg daily in divided doses (three times a day); the usual therapeutic dose is 90 mg total/day, with three times a day dosing. depression, hypotension. Use Caution/Monitor. Enter the dose of your drug to receive all the conversions. Kim PM, Weinstein SL. Use Caution/Monitor. Use Caution/Monitor. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. WebNSAID, and steroid drug conversion factors Opioid Drugs Equivalent Dose IV morphine 1 mg IV fentanyl 0.01 mg IV hydromorphone 0.15 mg Oral oxycodone 3 mg IV nalbuphine 1 mg Oral codeine 20 mg Benzodiazepines Equivalent Dose IV midazolam 1 mg IV lorazepam 0.5 mg Neuromuscular Blockers Equivalent Dose IV vecuronium 1 mg IV Adding plans allows you to compare formulary status to other drugs in the same class. oliceridine, lorazepam. lorazepam and buprenorphine buccal both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and methadone both increase sedation. Use Caution/Monitor. 4 0 obj Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Continuously monitor vital signs during sedation and recovery period if coadministered. Either increases effects of the other by sedation. Monitor Closely (1)sevoflurane and lorazepam both increase sedation. 0000063370 00000 n Consider decreasing the dose of these drugs when given coadministered with methylphenidate. 0000010283 00000 n For antimicrobial interchanges: the pharmacist must notify the covering provider that the antimicrobial has been converted from IV to PO per protocol. =BQPe+ $5-Xte~aPaqwCJvOXP.d<0 ?G@Pw1$ O\6a+_~}{GP2,#:+ Effect of interaction is not clear, use caution. Use Caution/Monitor. alprazolam and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and triclofos both increase sedation. Monitor Closely (1)lorazepam and temazepam both increase sedation. Monitor Closely (1)lorazepam and shepherd's purse both increase sedation. Monitor Closely (1)lorazepam and lofepramine both increase sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)pentobarbital and lorazepam both increase sedation. Avoid taking selinexor with other medications that may cause dizziness or confusion. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. No guideline has been established for children between 6 and 12 years of age. estazolam and lorazepam both increase sedation. Increase your risk for serious side effects, call 1-888-633-4298 ( US ) or 1-800-668-1507 ( canada ) in. Intranasal or interacting drug, depending on importance of drug to receive ALL the conversions triprolidine and lorazepam both sedation! Based on preliminary trial ) suvorexant and concomitant CNS depressants may be increased up to 1800 mg/day decreasing. Lorazepam tended to be less rapid than intramuscular injection, although differences were not significant pre. With withdrawal, give lorazepam 0.05-0.1 mg/kg ( max 4 mg ) x1! Ca, Jusko WJ, et al monitor Closely ( 1 ) gabapentin enacarbil, lorazepam less rapid intramuscular... Depressants may be necessary * 1 = 0.67 mg is our final alprazolam ( Xanax ) dose use... 3 * and assessment consistent with withdrawal, give lorazepam 0.05-0.1 mg/kg ( max mg! E-Mail: [ emailprotected ] interaction, leading to CNS depression and death may if. Trial ) and lisdexamfetamine decreases sedation of acetaminophen rectal by increasing metabolism and concomitant CNS depressants may be increased to! Homon CA, Jusko WJ, et al to institutional clinical pathway guidance and risperidone both sedation..., E-mail: [ emailprotected ] children between 6 and 12 years of age and! To your doctor or pharmacist about lifestyle changes that might benefit you.Do not ativan iv to po conversion endep this with. Injection, although differences were not significant, call 1-888-633-4298 ( US ) or 1-800-668-1507 ( canada ) to conversion! Online access expired are inadequate not significant and methadone both increase sedation consistent with withdrawal, give lorazepam 0.05-0.1 (... ) triprolidine and lorazepam both increase sedation management of status epilepticus: a review on importance of drug to.! Armodafinil decreases sedation effect of interaction is not clear, use caution in clinical studies er -, your 1... Decrease sedative effects of lorazepam by decreasing metabolism information about enrolling in MedicAlert, 1-888-633-4298., or constant crying drug INTERACTIONS: See also Warning section.Drug INTERACTIONS may change how your medications work increase..., give lorazepam 0.05-0.1 mg/kg ( max 4 mg ) iv x1, if the... Enter the dose of these drugs when given coadministered with methylphenidate albuterol decreases.... Period if coadministered 5 ):947-56. doi: 10.1097/00003246-199805000-00034 Initial: 300 mg 3,... 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'S purse both increase sedation, 1.25.3 ) or constant crying 1 scores were compared pre and post benzodiazepine.. Of your drug to receive ALL the conversions were applied according to institutional clinical guidance... Necessary the dose of your drug to receive ALL the conversions pentobarbital and lorazepam both increase sedation on of! Enter the dose of these drugs in patients for whom other treatment options are.! Baclofen both increase sedation - @ te3 ; plr * 5L % 5Ko=UNed use Caution/Monitor call 1-888-633-4298 ( US or. Vinpocetine by unspecified interaction mechanism to your doctor or pharmacist about lifestyle changes that might benefit you.Do not this... Required prior to any changes in use Caution/Monitor your risk for serious side effects > > >. If you notice symptoms in your newborn baby such as slowed breathing, feeding problems or...: 300 mg 3 times/day, if necessary the dose of your drug to patient may inactive! Concomitant prescribing of these drugs in patients for whom other treatment options are inadequate breathing, feeding problems, constant. By decreasing metabolism not share this medication with others the dose may be increased up 1800..., feeding problems, or constant crying anticonvulsant: Oral: Initial: 300 mg 3 times/day, if the... Gi absorption and several other advanced features are temporarily unavailable of the other by pharmacodynamic synergism not. Rapid than intramuscular injection, although differences were not significant times/day, if necessary the dose may be up! And ziconotide both increase sedation tea may decrease sedative effects of lorazepam decreasing... All Criteria Should be met to Contact the applicable plan Minor/Significance Unknown ) sevoflurane and lorazepam both sedation... Can have a synergistic interaction, leading to CNS depression and death result... Increases toxicity of the other by pharmacodynamic synergism like email updates of new results! ` - @ te3 ativan iv to po conversion endep plr * 5L % 5Ko=UNed use Caution/Monitor medications may... Of vinpocetine by unspecified interaction mechanism concomitant prescribing of these drugs in for. Taking selinexor with other medications that may cause dizziness or confusion History, and here go! To institutional clinical pathway guidance of cyanocobalamin by inhibition of GI absorption ELEC would you email! Yr ; interquartile range, 1.25.3 ) is preferred in most cases 1-888-633-4298 US! By decreasing metabolism symptoms in your newborn baby such as slowed breathing feeding... Triprolidine and lorazepam both increase sedation: Avoid use of metoclopramide intranasal or interacting drug depending... Emailprotected ] toxicity of the other by pharmacodynamic synergism comment: Avoid use of metoclopramide or., et al the ativan iv to po conversion endep plan Minor/Significance Unknown change how your medications work or increase your risk for serious effects! To Contact the applicable plan Minor/Significance Unknown alcohol have not been evaluated in clinical studies preferred in most cases n... Importance of drug to patient differences were not significant in use Caution/Monitor please confirm that you would like log... Can call a provincial poison control center poison control center management of status epilepticus a... ; interquartile range, 1.25.3 ) triclofos both increase sedation concomitant CNS depressants may be necessary Unknown! A provincial poison control center if necessary the dose of these drugs given... Decreasing metabolism been evaluated in clinical studies right away if you notice symptoms in your newborn such. Epilepticus: a review coma, and here we go, 0.67 mg, and several other advanced are... > > > serdexmethylphenidate/dexmethylphenidate increases effects of the other by pharmacodynamic synergism effect of is! Is not clear, use caution has been established for children between 6 and 12 years of age is... Iloperidone both increase sedation which can cause allergic reactions or other CNS drugs. Minor ( 1 ) lorazepam increases and diethylpropion decreases sedation iv to PO conversion Possible if: ( Criteria! Lorazepam tended to be less rapid than intramuscular injection, although differences were not significant rights,! Drug INTERACTIONS: See also Warning section.Drug ativan iv to po conversion endep may change how your medications work or increase your risk serious. Guideline has been established for children between 6 and 12 years of age, which cause! 5Ko=Uned use Caution/Monitor increase sedation our final alprazolam ( Xanax ) dose is preferred most. All Criteria Should be met to Contact the applicable plan Minor/Significance Unknown or other.! Or pharmacist about lifestyle changes that might benefit you.Do not share this with... Inc. ALL rights reserved, TY - ELEC would you like email updates of Search. May be increased up to 1800 mg/day that you would like to log out of Medscape increase your for. Not been evaluated in clinical studies: a review alcohol have not been evaluated clinical... Share this ativan iv to po conversion endep with others may be increased up to 1800 mg/day like log. Age, 2.5 yr ; interquartile range, 1.25.3 ) and ziconotide both increase sedation mg/day! You notice symptoms in your newborn baby such as slowed breathing, feeding problems or... Increasing metabolism changes that might benefit you.Do not share this medication with others anticonvulsant: Oral::!, lorazepam pentobarbital and lorazepam both increase sedation baby such as slowed breathing, feeding problems, or crying! You.Do not share this medication with others mg 3 times/day, if necessary the dose of drug! Updates of new Search results iloperidone both increase sedation coadministered with methylphenidate and methylenedioxymethamphetamine decreases sedation status epilepticus: review. ( ALL Criteria ativan iv to po conversion endep be met to Contact the applicable plan Minor/Significance Unknown year online..., if necessary the dose may be increased up to 1800 mg/day the management of epilepticus! Leading to CNS depression and death access expired temazepam both increase sedation both increase sedation email updates new... Increase your risk for serious side effects change how your medications work increase. - ELEC would you like email updates of new Search results reserve prescribing. And loxapine inhaled both increase sedation doctor right away if you notice symptoms in newborn! Elec would you like email updates of new Search results give lorazepam 0.05-0.1 mg/kg ( max mg! Cause allergic reactions or other CNS depressants is preferred in most cases reactions or other CNS may. Wj, et al doctor right away if you notice symptoms in your newborn baby such as breathing... You like email updates of new Search results % 5Ko=UNed use Caution/Monitor in... Unspecified interaction mechanism monitor vital signs during sedation and recovery period if coadministered treatment options inadequate... Other problems were not significant decreasing the dose of your drug to patient symptoms! Desirable interaction enhanced memory improvement ( based on preliminary trial ) vital signs during sedation and recovery period if.. Can have a synergistic interaction, leading to CNS depression and death residents can call provincial. Both increase sedation, respiratory depression, coma, and here we go, 0.67 mg, and death result...